Devon and Cornwall Constabulary caught 335 people drink-driving over the Christmas period.
The Force is encouraging members of the public who know or suspect people who drink-drive to contact the police anonymously so that they can act on the tip-offs.
Inspector Richard Pryce, of the Force's Traffic Unit, said: "Drink-driving is totally unacceptable and shows a serious lack of respect for other road-users. It is a blatant disregard for the devastating and life-changing impact it can have on anyone involved when collisions occur. Families can be left totally devastated and it is entirely avoidable."
The Force administered 3,178 breath tests from December 1 2006 to January 1 2007, with 335 positive, refused or failed.
"This figure is 335 people too many, and they clearly did not heed the advice given. When judgement is impaired, behind the wheel of a vehicle is not the place to be. As always, we will continue to robustly target drink-drivers every day of the year," he added."It is clear that a small number of road-users feel that drinking and driving is a risk worth taking - my message to people who know of this activity is to report it to the police. We can follow up the information and take these people off the road."
Those convicted of drink-driving can expect to lose their driving licence for at least a year; a fine of up to £5,000 and six months in jail.
Death or serious injury while under the influence of alcohol carries a maximum penalty of 10 years in prison.
During the 2005 Christmas drink-drive campaign, the Force administered 1,918 breath tests, with 264 positive, refused or failed.
In the latest campaign 117 proved positive, refused or failed a breath test in Cornwall, 55 in Plymouth, 79 in south and west Devon and 84 in north and east Devon.
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